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Canine degenerative myelopathy

Canine degenerative myelopathy (DM) is a slowly, progressive adult-onset neurodegenerative disease causing paralysis similar to human amyotrophic lateral sclerosis (ALS – Lou Gehrig’s disease). Canine DM was first described by Averill in 1973 as an insidious, progressive, general proprioceptive (GP) ataxia and upper motor neuron (UMN) spastic paresis of the pelvic limbs ultimately leading to paraplegia and necessitating euthanasia.

Diffuse Large B-Cell Lymphoma

Diffuse large B-cell lymphoma (DLBCL) is a hematopoietic tumor of B-cells. It is the most common type of non-Hodgkin lymphoma in both people and dogs, with an annual incidence of 15.5-29.9 per 100,000 people and 15-30 per 100,000 dogs. 


Epilepsy is a chronic neurological condition characterized by unpredictable seizures, and it affects both humans and animals. Management of epilepsy is often challenging, especially with Dravet syndrome and Lennox-Gastaut syndrome, which both manifest as early-onset, treatment-resistant epilepsy in young children.

Inflammatory Bowel Disease

Inflammatory bowel disease (IBD) involves chronic inflammation of the gastrointestinal (GI) tract. In humans, there are 2 major forms of IBD: Ulcerative Colitis (UC) and Crohn’s Disease. While both are characterized by chronic inflammation they differ in which tissue layers are affected and the location and continuity of inflammation.

Mitral Valve Disease

Mitral valve disease (MVD) can be congenital (a defect in the valve the patient is born with) or acquired (valve conditions that develop with aging or due to infection) and includes both mitral valve regurgitation (a leaky valve) and mitral valve stenosis (a narrow valve that cannot open).


Osteosarcoma (OS) is the most common primary bone tumor in both dogs and people. While the disease incidence is relatively low in people (800-1000 cases/year), over 25,000 new cases are diagnosed in dogs every year. Most dogs develop OS at approximately 7 years of age, with a smaller early peak in younger dogs.

Spinal Cord Injury

Intervertebral disc herniation (IVDH)- associated SCI is the most common cause of SCI in pet dogs, with upwards of 20,000 cases managed by veterinary spinal surgeons in the United States every year.

Urothelial Carcinoma

Urothelial carcinoma (“UC”, also called transitional cell carcinoma) is the most common type of urinary bladder cancer in dogs and humans.