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Animal Disease Models

Both animals and people develop many of the same diseases. These animal disease models detail the similarities and differences of diseases between species.

We invite COHA members to share additional Animal Disease Models, using the links below.

Boxer Cardiomyopathy

Cardiomyopathy is the human equivalent of this condition.

Canine degenerative myelopathy

Canine degenerative myelopathy (DM) is a slowly, progressive adult-onset neurodegenerative disease causing paralysis similar to human amyotrophic lateral sclerosis (ALS – Lou Gehrig’s disease). Canine DM was first described by Averill in 1973 as an insidious, progressive, general proprioceptive (GP) ataxia and upper motor neuron (UMN) spastic paresis of the pelvic limbs ultimately leading to paraplegia and necessitating euthanasia.

Diffuse Large B-Cell Lymphoma

Diffuse large B-cell lymphoma (DLBCL) is a hematopoietic tumor of B-cells. It is the most common type of non-Hodgkin lymphoma in both people and dogs, with an annual incidence of 15.5-29.9 per 100,000 people and 15-30 per 100,000 dogs. 

Epilepsy

Epilepsy is a chronic neurological condition characterized by unpredictable seizures, and it affects both humans and animals. Management of epilepsy is often challenging, especially with Dravet syndrome and Lennox-Gastaut syndrome, which both manifest as early-onset, treatment-resistant epilepsy in young children.

Equine Ocular Squamous Cell Carcinoma

Ocular squamous cell carcinoma (SCC) is a form of neoplasia (e.g. cancer) affecting the eye of both animals and humans. Ocular SCC is relatively rare in humans, affecting 1 in 1,000,000 people in regions outside of Africa.

Feline Chronic Kidney Disease

Chronic kidney disease (CKD) is reported in 1-3% of cats with an estimated one-third of cats developing CKD in their lifetime. In the US, 15% of adults, 37 million people, have CKD. In both cases, the disease prevalence increases with age: an estimated 38% of people over 65 years old and approximately 30% to 80% of cats over 15 years old live with CKD.